Abstract Library

#1184 A National Pathology Registration Analysis of Applied Terminology in Pulmonary Neuroendocrine Tumors/Carcinomas: Is the WHO 2004 Classification in Line with Clinical Practice?

Introduction: Nomenclature of the WHO 2004 should be used for pulmonary neuro-endocrine tumors (NET) and carcinomas (NEC) classification.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Derks J

Authors: Derks J, Dingemans A, Van Suylen R, Thunnissen E, Den Bakker M,

Keywords: NET, Diagnosis,

#653 Interobserver Variability of Pulmonary Carcinoids

Introduction: Lung carcinoids are neuroendocrine tumors histopathologically classified into typical (TC; no necrosis, <2 mitoses/2 mm2) and atypical (AC; necrosis or 2-10 mitoses/2 mm2). Identification of mitoses may be hampered by the presence of apoptotic cells, and reported prediction of prognosis based on histopathology varies, especially for ACs.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Swarts D, Van Suylen R, Den Bakker M, Van Oosterhout M, Thunnissen E,

Keywords: lung carcinoids, classification, histopathology, interobserver variation, orthopedia homeobox, MIB-1,

#462 Genome-Wide Expression Profiling Reveals Downregulation of OTP and CD44 and Upregulation of RET as Indicators of Poor Prognosis in Lung Carcinoids

Introduction: Lung carcinoids comprise a heterogeneous group of neuroendocrine tumors. Only few parameters have been identified that correlated with poor disease outcome, including 11q22-q25 deletions. New biomarkers are required to further improve diagnosis and prediction of prognosis.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Swarts D, Van Neste L, Henfling M, Van Suylen R, Volante M,

Keywords: Bronchial carcinoids, cDNA microarray, MEN-2,

#212 Reduced MEN1 Gene Expression in Pulmonary Carcinoids Is Associated With Metastatic Disease

Introduction: Lung carcinoids are neuroendocrine tumors that can be classified as typical (TC) or atypical (AC) carcinoids. Previously, MEN-1 mutations and associated LOH of 11q13 have been implied in tumorigenesis.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Swarts D, Henfling M, Ramaekers F, Van Suylen R, Dingemans A,

Keywords: bronchial carcinoids, methylation specific PCR, multiple endocrine neoplasia type 1, hypermethylation,

#65 Deletions of 11q21-q25 are associated with atypical lung carcinoids and a poor clinical outcome

Introduction: Lung carcinoids comprise a group of smoking-unrelated neuroendocrine tumors, which can be classified in typical (TC) and atypical (AC) carcinoids. Classification is complex and its accuracy to predict disease outcome is variable. In a previous array comparative genomic hybridization (arrayCGH) study, we showed that the average number of chromosomal alterations (≥ 1Mb) was significantly higher in ACs than in TCs (512 v. 226 per tumor) and that the most common region of chromosome loss was 11q21-q25 (Neuroendocrinology 2009;90:136-137).

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Swarts D

Authors: Swarts D, Van Suylen R, Dingemans A, De Herder W, De Krijger R,

Keywords: pulmonary carcinoids, array CGH, survival, 11q deletion, prognosis,